Download 184.108.40.206 - [PLUGIN] Update JNews - Split Post. Undo Function for more convenient editing; Enable PHP functions for easier editing for non-technical users; Auto Image Convert and Auto Facebook Image Convert - Download Free. Html Edt provide simple solution to edit and create HTML code.Prenatal diagnosis of beta-thalassemia: the impact of the study center and the importance of fetomaternal blood transfusion.
Forty-four couples, at risk for beta-thalassemia, underwent prenatal diagnosis of beta-thalassemia and their pregnancies followed up during the first trimester. Blood samples, obtained from the mother and the fetus, were tested using the pretested High Performance Liquid Chromatography (HPLC) and the High Performance Capillary Electrophoresis (HPCE) techniques. The HPCE was found to be more accurate and sensitive and was more useful for the diagnosis of both beta-thalassemia intermedia and major. Cordocentesis was carried out in all fetuses but due to the small amount of blood, a blood transfusion was given to 19. The overall beta-thalassemia mutations found were codon deletion 39 [CD39 (-)], codon 17 [CD17 (-)], CD41 (-) and codon 16 [CD16 (-)]. The genetic counseling in 32 of the 44 couples did not change the attitude to the management of their pregnancies in the 37 pregnancies that were subsequently detected. In the seven pregnancies where further genetic testing was necessary, the counseling did not influence the management of the pregnancy in all but one case where the couple was concerned about the poor outcome of the pregnancy in the homozygous fetus. The importance of prenatal diagnosis and fetal blood transfusion is discussed.Individualised treatment of gastro-oesophageal reflux disease: 'on-demand' versus 'pro re nata' proton pump inhibitor therapy.
Proton pump inhibitor (PPI) therapy is the mainstay of treatment of gastro-oesophageal reflux disease (GORD). However, it is well recognised that in some patients the initial symptom resolution is poor with PPI therapy. The efficacy and safety of PPI therapy 'on demand' has been questioned, in particular the implications for symptom recurrence after dose reduction or discontinuation. The post hoc efficacy analysis from three prospective, randomized, double 0b46394aab